In the near future, Earth has been ravaged by climate changes, leading to massive food shortages and dust storms that threaten humanity's survival. Cooper, a former NASA pilot-turned-farmer, stumbles upon a secret NASA facility led by Professor Brand, where he learns about a plan to find a new home for humanity. Scientists have discovered wormholes near Saturn, which open pathways to potentially habitable planets in another galaxy. Cooper joins a team of astronauts, including Brand's daughter, Amelia, on a daring mission through the wormhole to evaluate these planets and secure humanity's future.

The team faces numerous challenges in their interstellar journey as they search for a viable planet. Their mission is fraught with difficult decisions, personal sacrifices, and the straining of time itself due to the effects of relativity. Back on Earth, Cooper's family struggles with his absence and the worsening environmental conditions, adding a sense of urgency to the mission's success. The team must navigate not only the vast unknowns of space but also the depths of their own humanity and determination to save their loved ones and the species as a whole.