The movie follows the adventures of Cheech and Chong, two perpetual stoners, as they navigate through a series of absurd and comical situations. The narrative begins with the duo trying to make money through various unconventional means, often leading to chaotic and hilarious outcomes. Their laid-back demeanor contrasts sharply with the unpredictable environments and eccentric characters they encounter. Each misadventure highlights their unique bond and shared love for unconventional problem-solving.

As they continue their journey, Cheech and Chong find themselves entangled in more bizarre scenarios that underscore their carefree attitude toward life. They often outwit or simply stumble past numerous challenges, creating a tapestry of humorous and offbeat moments. The duo's interactions are marked by witty banter and outlandish escapades that keep the energy lively. The animated format adds an extra layer of surrealism, amplifying the comedic antics and visual gags, ensuring that their journey is a series of unpredictable and laugh-out-loud funny experiences.