In the rural countryside, Farmer Vincent Smith and his sister Ida run a remote motel called the Motel Hello (the "o" in the neon sign frequently flickers out). Unbeknownst to most, Vincent has developed a secret and sinister specialty aside from the hospitality business: he produces and sells what is known locally as the best smoked meat in the region. Tourists and passersby are lured into the motel through a variety of deceptive practices where the siblings' hospitality takes a dark turn.

Vincent and Ida's unusual agricultural methods involve a gruesome secret ingredient that underpins their meat-smoking success. The siblings use a twisted form of farming, capturing unwary visitors and preparing them for their special recipe. Meanwhile, the local sheriff, Vincent’s naive younger brother Bruce, is oblivious to the grim activities taking place at the motel. Amidst their operations, the situation grows more complicated when a young woman named Terry arrives, and Vincent starts developing feelings for her, creating a potential disruption to the grotesque family tradition.