A mysterious corporation called Watershed enlists five individuals to explore the dark side of human senses through twisted experiments. Each segment delves into one of the five senses—sight, sound, touch, taste, and smell—unveiling a different character's encounter with horrifying and surreal occurrences. As they undergo these nightmarish experiences, the characters find themselves trapped in a web of manipulation and deceit, questioning the boundaries of reality and perception. The corporation's true intentions are shrouded in secrecy, adding layers of psychological tension and fear.

In the segment on sight, a man using a pair of innovative contact lenses begins to witness horrifying visions. The sound segment follows a DJ who discovers a disturbing frequency with deadly consequences. The touch storyline reveals a masseuse encountering an unusual client whose desires lead to physical and psychological torment. In taste, a chef is introduced to a rare ingredient that delivers unexpected side effects. The final segment on smell trails a blind recluse whose heightened olfactory senses open up a world of terror. Each story intertwines, contributing to an overarching narrative that examines the fragility of human perception while leading the characters down a path of irreversible horror.