A documentary film crew sets off on a journey down the Amazon River to discover and film a lost indigenous tribe. The crew, led by an ambitious director and her determined cinematographer, navigates through the lush but treacherous jungle in hopes of achieving cinematic glory. Their expedition takes an unexpected turn when they rescue a stranded snake hunter, who claims to have vast knowledge of the area and offers to guide them to the tribe. Despite initial reservations, the team reluctantly accepts his help, unaware of the true nature of his intentions.

As they delve deeper into the heart of the Amazon, the crew begins to realize that they are being led on a dangerous detour. The hunter's obsession with capturing the world's largest and deadliest snake, the anaconda, becomes evident, setting the stage for a harrowing struggle for survival. Tensions within the group escalate as they are forced to confront not only the perilous environment and the creatures that inhabit it but also the treachery within their ranks. As they progress further into the snake's territory, they must band together to navigate the deadly challenges that lie ahead, all while questioning the trustworthiness of the guide who has led them into this nightmare.