The series revolves around the life of a comedian living in New York City and his eccentric group of friends. The main character, who is a stand-up comic, often finds himself in absurd situations that stem from everyday social interactions and the minutiae of city life. His quirky neighbor frequently stumbles into his apartment with odd schemes and behavior that often defy logic. Another integral friend is an ex-girlfriend who is now part of the social circle, sharing her own humorous experiences, navigations, and challenges with single life, dating, and work. The dynamics among the friends often highlight the comedic aspects of misunderstandings and personal quirks.

Each episode explores different scenarios ranging from social faux pas to the nuances of romance, work challenges, and personal rivalries. A key theme is their tendency to turn trivial incidents into absurdly complicated predicaments. Many episodes are characterized by witty banter and observational comedy, reflecting the characters' unique perspectives on life's minor annoyances. Various side characters contribute to the constant mayhem, keeping the series lively and unpredictable. Through its seemingly simple premise, the show captures the humor found in everyday life without relying on a traditional narrative structure, instead embracing a "show about nothing" approach that emphasizes character interactions over plot-driven storylines.