In an idyllic suburban neighborhood in California, Dr. Oliver Frank, the secretive grandson of the infamous Dr. Frankenstein, carries on his grandfather's legacy by conducting clandestine experiments in his lab, hidden within a sprawling estate. Despite the serene facade, he harbors a twisted ambition to create life, which manifests in his covert bio-engineering projects. His unsuspecting assistant, Dr. Elsu, remains oblivious to the true nature of their work, believing their research to be for the good of humanity. The first signs of trouble emerge when local teenagers, including Oliver's niece Trudy Morton, encounter a monstrous creature that has been lurking in the vicinity of Oliver's laboratory.

The creature, a grotesque and seemingly uncontrolled female monster created by Oliver, starts to wreak havoc in the neighborhood. Meanwhile, Trudy's boyfriend, Johnny Bruder, begins to grow suspicious of Oliver's odd behavior and sudden night-time activities. Trudy herself experiences strange and disturbing transformations, unaware that she's become an unwilling participant in her uncle's inhuman experiments. As the occurrences involving the creature become more frequent and violent, Johnny and his friends set out to uncover what's happening behind the closed doors of Dr. Frank's estate. Their investigation leads them closer to the truth, revealing the chilling reality of Oliver's disturbed vision and the lengths to which he will go to achieve his goals.