Terry McCaleb, a retired FBI profiler, has just undergone a heart transplant surgery after suffering from severe heart damage during his last case. McCaleb is trying to lead a quiet life, recuperating on his boat and adhering to his doctor's strict health guidelines. However, his retirement is abruptly interrupted when he is approached by Graciela Rivers. She informs him that his new heart belonged to her murdered sister, Gloria, and she implores him to take up her sister's murder case. Initially reluctant, McCaleb is eventually drawn in by a sense of duty and the personal connection he now shares with the victim.

As McCaleb delves deeper into the investigation, he uncovers a complex web of clues that suggests the killer's modus operandi is eerily similar to one he has encountered in his past FBI cases. His inquiries lead him into dark corners of the city's crime world, and he must navigate through a myriad of false leads and dangerous situations. With the help of his neighbor, Buddy, and despite the protests of his cardiologist, Dr. Bonnie Fox, who worries about the impact this stress will have on his heart, McCaleb is determined to solve the case. His dedication not only serves his sense of justice but also becomes a personal quest for redemption, as he seeks to give Gloria's heart a second chance at justice by finding her killer.