Pedro De Pacas is a down-and-out cholo who meets Anthony "Man" Stoner, a rich kid turned bum, after the pair hitch a ride together. Their journey starts when they realize they share a love for marijuana, leading them to bond over humorous mishaps and misunderstandings. One of their first adventures together involves crafting a joint the size of a burrito, sparking misadventures that result in them getting kicked out of a nightclub. As they avoid law enforcement, the two form an unlikely friendship, and their quest for the next high takes them from run-ins with local tough guys to run-ins with clueless policemen.

An inept police sergeant becomes obsessed with catching Pedro and Anthony, setting up roadblocks and inadvertently causing more chaos. Along the way, the pair stumbles upon a potential gig at a rock concert, hoping it might elevate their lifestyle from aimless stoners to something more meaningful. However, their efforts are constantly derailed by absurd circumstances and their own incompetence. The film's earlier scenes focus on their comedic escapades and the colorful characters they encounter, each episode revealing more about the duo’s laid-back philosophy and resilience amid life's absurdities.