In the early 1960s, a British explorer named John Hamilton ventures into the Amazon jungle accompanied by his guide and a team of scientists. They seek a mysterious lost city rumored to be hidden deep within the treacherous territory. Their journey is perilous, encountering hazardous terrain, hostile natives, and violent wildlife. As they press deeper into the unforgiving wilderness, they uncover disturbing signs of previous expeditions that met grim fates. Hamilton becomes aware that they are not the only ones interested in this ancient place; a sinister force is at work, leaving a trail of destruction.

Hamilton's expedition soon crosses paths with a Nazi fugitive who has established a secluded compound in the heart of the jungle. The fugitive is linked to horrifying experiments carried out during World War II, and his survival hinges on the secrets buried in the lost city. As Hamilton and his dwindling group attempt to navigate the growing dangers around them, they face a desperate race against time and evil. Their journey reveals darker truths that challenge their mission’s purpose. The relentless quest pushes Hamilton beyond his limits, but to uncover the truth, survival becomes a battle against both man and nature’s most vile creations.