Set in the late 1940s through the 1970s, an elderly Jewish widow named Daisy Werthan lives in Atlanta, Georgia. After a car accident, her son Boolie insists on hiring a driver for her safety, despite her resistance to the idea. Hoke Colburn, an African American chauffeur, is employed for the job. Initially, Miss Daisy is dismissive and distrustful of Hoke, reluctant to give up her independence and stubbornly refusing his assistance. Despite her aloof behavior, Hoke remains patient and respectful, gradually building a rapport with her through small acts of kindness and perseverance.

Over the years, the relationship between Miss Daisy and Hoke evolves from employer and employee to a deep, enduring friendship. As they share personal stories and navigate social and racial changes in the South, they develop a mutual understanding and respect for each other. Their journey reflects broader themes of changing social dynamics, aging, and the power of human connection. The narrative highlights the evolving dynamics between two individuals from different backgrounds as they bond over time.