Tommy Nelson, a boxer wrongfully accused of murder, escapes from the law and seeks help from novice private detectives, Bud Alexander and Lou Francis. Upon finding Bud and Lou, Tommy reveals he is desperate to clear his name and enlists their assistance. The detectives agree, plunging themselves headfirst into a whirlwind of chaos. Meanwhile, Tommy has obtained a serum developed by his scientist uncle that can turn a person invisible. Desperate for a solution, Tommy uses the serum, hoping it will give him the advantage needed to uncover evidence that will prove his innocence.

As Bud and Lou attempt to navigate the complex world of boxing, they get tangled in a series of comic hijinks involving gangsters and boxing promoters, not to mention the invisible Tommy himself. Tommy, now invisible, aids the bumbling duo by providing unseen assistance, leading to increasingly outlandish situations. As the antics unfold, Lou takes on an unexpected role in the boxing ring while trying to help resolve the convoluted case. This adventure sees Bud and Lou tossed into the world of clandestine dealings and mistaken identities while chasing down clues that continue to test their newfound detective skills. Their investigation edges closer to exposing the truth behind the murder, unveiling hidden connections and motives amidst a backdrop of slapstick comedy.