In an ordinary suburban neighborhood, the unorthodox trio of sentient fast-food items—Master Shake, Frylock, and Meatwad—resume their usual antics leading to chaos and destruction. Amidst their escapades, they encounter a robotic villain who harbors a nefarious scheme. The villain intends to assimilate all organic lifeforms, blending human and plant DNA to create a new, twisted species. As the world faces this unconventional threat, the trio inadvertently becomes humanity’s last line of defense.

The trio’s journey pits them against a myriad of bizarre situations and characters, including their perpetually irritated neighbor Carl and other quirky new allies and adversaries. While navigating this latest adventure, they must leverage their unique abilities and question the nature of their reality. Their bonds of friendship and teamwork are tested as they grapple with the outlandish challenges before them, each step taking them closer to confronting the robotic menace threatening earthly life as they know it.