A group of college friends decides to spend their spring break on a remote island owned by the wealthy and eccentric Muffy St. John. The visitors look forward to a weekend of fun, partying, and relaxation at Muffy's family mansion. Upon arrival, the atmosphere is ripe with anticipation for the playful pranks and jokes inherent to the time of the year, April Fool's Day. The friends are keen on enjoying a break from their routine lives, embracing the isolation and the unique setting for their holiday. Muffy, welcoming and mysterious, has prepared a series of April Fool's Day pranks to entertain her guests, aiming to make the weekend memorable.

However, as the weekend progresses, the initial harmless pranks gradually take a dark turn, leading to a series of strange and frightening events that hint at a sinister reality beneath the surface. The group's excitement soon turns to horror when they begin to disappear one by one under mysterious circumstances. What was supposed to be a leisurely holiday quickly spirals into a nightmare, as the line between harmless pranks and dangerous realities blurs. The friends must unravel the mystery behind their terrifying ordeal, questioning what is real and what is not, while struggling to survive on the isolated island cut off from the outside world.