The story follows Mark Twain as he embarks on a fantastical journey to find Halley's Comet, believing his destiny is linked to it. Accompanied by his iconic literary characters Tom Sawyer, Huck Finn, and Becky Thatcher, Twain sets sail in an airship designed in the shape of a riverboat. Throughout their voyage, they encounter imaginative scenarios that bring Twain's beloved stories to life, blending whimsical adventure with profound reflections on humanity. The crew navigates through a series of surreal and allegorical episodes, where Twain and his companions experience his tales and meet some of the colorful characters from his books.

As the journey progresses, Twain delves into themes of life, death, and the pursuit of one's dreams. Interspersed with humor and moral lessons, the trio learns valuable insights from their creator. Twain's interactions with his characters provide a deeper understanding of his mind and philosophy, captured in the animated, claymation style that adds a unique texture to the storytelling. The voyage not only illuminates Twain's inner world but also reinforces the timeless nature of his literary contributions. The narrative culminates in a poignant conclusion, emphasizing the enduring impact of Twain's work on readers and the literary world.