Dr. Henry Tibbett, a small-town physician, finds his practice dwindling as patients flock to a new doctor in town. Struggling with financial difficulties, he is approached by circus performer Professor McCrackle, whose prized elephant Zenobia has fallen ill. Dr. Tibbett manages to successfully treat Zenobia, earning the lasting gratitude of the pachyderm. Zenobia becomes extremely attached to him and insists on following him everywhere, causing amusing chaos and unwanted attention around the town.

Tibbett’s bond with the elephant strains his relationships with friends and neighbors, who view the situation as increasingly inappropriate. Despite these challenges, he retains his dedication to Zenobia's well-being while attempting to restore balance in his life and career. His perseverance against societal pressures highlights his true character and dedication. As tensions build within the community and Dr. Tibbett's life edges toward turmoil, unforeseen events begin to dramatically alter the course of his personal and professional journey.