Dusty Crophopper, a crop-dusting plane with dreams of becoming a racing champion, spends his days working in the fields and practicing aerobatic maneuvers in his free time. Despite his inherent fear of heights and lacking the design typically required for high-speed competition, Dusty remains determined to prove that he has what it takes. He seeks guidance from Skipper Riley, a reclusive old naval aviator, who reluctantly agrees to mentor him. With Skipper's help, Dusty qualifies for the prestigious Wings Around the Globe race, where he faces off against experienced racers from all over the world.

During the competition, Dusty encounters various challenges that test his skills and resilience while making new friends and facing rivals who push him to his limits. Along the way, he learns important lessons about courage, perseverance, and what it truly means to be a winner. As the race progresses, Dusty must overcome mechanical failures, adverse weather conditions, and his own insecurities. His journey is not just about winning the race but also about discovering his true potential and embracing who he is.