After his adventures with the Guardians of the Galaxy, the once-mighty Thor is on a personal quest of self-discovery and healing. His retirement is interrupted by a galactic killer known as Gorr the God Butcher, who seeks vengeance against the gods, threatening their existence across the cosmos. Driven by a deep personal tragedy, Gorr is on a relentless crusade to exterminate all deities, wielding an enigmatic and powerful weapon capable of slaying immortals. Thor's journey leads him to seek help from old allies and face his own godhood's purpose and legacy.

In his pursuit to stop Gorr, Thor enlists the aid of King Valkyrie of New Asgard, the rock-warrior Korg, and unexpectedly, his ex-girlfriend Jane Foster, who now mysteriously wields his magical hammer, Mjolnir, as the Mighty Thor. Their interactions reignite past affections and spark new conflicts as they navigate their evolved identities. Together, this unlikely band of heroes must confront their personal demons and band together to face the wrath of the God Butcher before he fulfills his genocidal mission. Amidst battles both intimate and epic, they explore the true meaning of heroism and sacrifice.