Set in a whimsical world of grand ambitions and outlandish technology, the story follows a pioneering effort to launch the world's first nuclear-powered luxury bus, a behemoth called Cyclops, on a non-stop journey from New York to Denver. Amidst the excitement of this unprecedented venture, tensions rise as the project faces sabotage threats from a rival consortium determined to see it fail. The peculiar crew and eclectic set of passengers, each with their own quirks and backstories, add to the inevitable chaos and comedy on this maiden voyage. The lead engineer, Kitty Baxter, and her estranged husband, Dan Torrance—the heroic yet disgraced driver—find themselves thrown together to save not only the journey but also their personal relationship.

As the journey progresses, mechanical failures and absurd challenges abound, leading to a series of misadventures that test the limits of the mega-vehicle and those aboard. Dan must prove his capabilities amidst an adversarial environment where threats loom large both inside and outside the bus. Plagued by memories of past mishaps and grappling with newfound pressures, he strives to navigate through these hurdles with aplomb. Meanwhile, passengers contribute their mix of comedic elements and human drama, turning a mere transit into a rollicking escapade filled with unpredictability and laughter. Amidst ongoing pandemonium, alliances are tested, and people forced to confront their fears and prejudices as they work together towards an uncertain future.