Will Sawyer, a former FBI Hostage Rescue Team leader and U.S. war veteran, now assesses security for skyscrapers. While on assignment in Hong Kong, he finds the tallest, safest building in the world suddenly ablaze and discovers he's been framed for it. A wanted man on the run, Will must find those responsible, clear his name, and somehow rescue his family, who is trapped inside the building, above the fire line.

As Sawyer navigates the complex structure and battles the raging inferno, he encounters a group of criminals with a mysterious agenda. These adversaries complicate his mission, turning the skyscraper into a towering, deadly battlefield. Meanwhile, his wife Sarah, a combat-trained surgeon, utilizes her skills to keep their two children safe and assists Will in his quest to outsmart the criminals. Together, they confront extreme dangers within the burning behemoth, fighting not only to save their family but to prevent the disaster from consuming the city below.