Primatologist Davis Okoye, a man who keeps people at a distance but shares an unshakable bond with George, an extraordinarily intelligent, silverback gorilla he has cared for since birth. When a rogue genetic experiment goes wrong, it causes George, a wolf, and a crocodile to grow to a monstrous size and gain incredible aggression. As the mutated beasts embark on a path of destruction, Okoye teams with discredited genetic engineer Dr. Kate Caldwell to secure an antidote, hoping to turn the tide and save George.

Their journey for a cure becomes increasingly perilous as they must navigate a battlefield filled with towering creatures and a relentless military response. Meanwhile, the corporation responsible for the disaster, Energyne, attempts to cover up their involvement and harness the creatures' genetic alterations for their own dubious purposes, adding a human threat to the already chaotic situation. The race against time intensifies as the mutated animals converge on Chicago, setting the stage for a colossal showdown that could have catastrophic consequences for the entire planet.