A decade has passed since the CIA's most lethal operative, Jason Bourne, emerged from the shadows. Having recovered from his amnesia, Bourne is trying to uncover the remaining pieces of his past while living off the grid and sustaining himself through bare-knuckle fighting in various European locations. But the world has changed with new political alignments and cyber strategies, as Bourne's history as a former operative becomes increasingly relevant and urgent.

Bourne's former colleague Nicky Parsons hacks into the CIA's mainframe to uncover more about their black ops and stumbles upon vital information about Bourne's recruitment and the death of his father. Nicky's actions alert the new CIA director Robert Dewey about the security breach, and he sends cyber expert Heather Lee and a lethal asset to track them down. The chase leads Bourne and Parsons to re-enter a world they thought they had left behind, with the CIA determined to silence them. As Bourne learns more about his past and the agency's new programs, the stakes get higher, setting him on a collision course with those who would stop at nothing to keep the secrets of his origins and the agency's operations hidden.