Louisa May Foster is a lively yet unlucky woman whose desire for a simple life is persistently thwarted by the untimely deaths of her wealthy husbands. Each marriage begins with humble aspirations, only for her husbands to find sudden, inexplicable success that leads to their eventual downfall. From a struggling artist who rockets to fame, to an unassuming farm owner who strikes oil, Louisa's life runs an ironic and often tragic course despite her genuine efforts to live simply and happily.

As Louisa recounts her story to a sympathetic psychiatrist, she reflects on the bizarre twists of fate that have left her both fabulously rich and profoundly lonely. Her journey through multiple marriages and varying walks of life exposes the absurdity of wealth and fame while showcasing her resilience and yearning for true love. Despite the comedy woven throughout her tale, Louisa's story raises questions about the nature of happiness and the cruel whims of destiny.