A plane en route from Sydney to Los Angeles crashes on a mysterious tropical island. The survivors, a diverse group of people with complex backgrounds, must band together to overcome adversity and survive despite the island's many dangers. Among the group are Jack, a determined doctor; Kate, a resourceful fugitive; Sawyer, a conman with a troubled past; Hurley, a lottery winner plagued by bad luck; Sayid, a former Iraqi soldier; and Sun and Jin, a married Korean couple burdened by secrets. As the survivors struggle with the harsh conditions and lack of resources, they encounter oddities such as wild polar bears and unexplainable phenomena that suggest the island isn't what it seems.

The survivors soon discover they are not alone on the island when they encounter other inhabitants known as "The Others," whose mysterious motives pose new threats. Intricately woven flashbacks reveal more about each character's backstory, while clues about the island's enigmatic secrets slowly unfold. As the group conflicts with one another and battles for survival, they are drawn into puzzling mysteries about the island's true nature and the events that brought them there. Tension rises as supernatural elements become more pronounced, hinting at a larger cosmic significance to their plight. As dynamics shift and personal stakes intensify, the survivors must confront their past mistakes and navigate a perilous journey towards understanding the island's deeper significance.