Frank Pierce is a worn-out paramedic working the graveyard shift in Manhattan. Haunted by the lives he couldn't save, particularly a young girl named Rose, he struggles with insomnia and hallucinations. His nightly duties bring him into contact with a mix of desperate strangers and fellow paramedics, including the blunt Larry, the excitable Marcus, and the jaded Walls. During a particularly grueling week, Frank becomes obsessed with saving a patient named Mr. Burke, who is in a coma but shows signs of recovery. As he moves from one harrowing call to another, Frank's fragile mental state begins to deteriorate, deepening his sense of guilt and helplessness.

Through his encounters, Frank meets Mary Burke, Mr. Burke's distraught daughter. Their interactions offer Frank brief moments of solace and connection amidst the chaos of his job. Yet, as he continues to confront death and suffering on a nightly basis, Frank finds himself slipping further into despair. Balancing on the edge between salvation and self-destruction, his journey explores themes of redemption, pain, and the blurred line between life and death.