Ned Rochlin is an overly trusting, kind-hearted organic farmer who ends up in jail after naively selling marijuana to a uniformed police officer. Upon his release, he finds himself homeless and decides to rely on his three sisters: Miranda, an ambitious journalist; Natalie, a bisexual, free-spirited stand-up comic; and Liz, a stressed-out mother of two. Each sister reluctantly takes him in, only to find that his unfailing honesty and childlike optimism turn their lives upside down. They struggle to deal with the chaos he brings into their meticulously planned existences.

Ned's innocence inadvertently reveals secrets and truths within his sisters' lives, leading to conflict and miscommunications. Despite their frustrations, they each come to realize that Ned's simple, sincere approach to life has impacted them in profound, positive ways. His unwavering belief in the goodness of people ultimately encourages them to reevaluate their own values and relationships. Through the arresting combination of humor and heart, the story explores the themes of trust, honesty, and family, concluding with the idea that sometimes the most seemingly foolish person can offer the greatest wisdom.