In the gritty streets of New York City, tough, no-nonsense detective, Daniel Madigan, and his partner, Rocco Bonaro, are tasked with capturing a notorious criminal, Barney Benesch. During a routine patrol, Madigan and Bonaro are outsmarted by Benesch, who manages to disarm them and make a thrilling escape. Under pressure from their superiors and facing intense scrutiny from Police Commissioner Anthony X. Russell, the detectives have only 72 hours to recapture the elusive fugitive while navigating the intricate web of corruption and bureaucratic red tape within their department. Russell himself grapples with moral and ethical dilemmas as he oversees this high-stakes manhunt.

As Madigan and Bonaro delve deeper into the criminal underworld, their resolve is tested by personal betrayals and the harsh realities of the life they lead. The story paints a vivid portrait of the strained relationships both men have with their respective families due to the demands of their profession. Tensions mount as they inch closer to their target, exposing connections between Benesch and influential figures that put them in even greater danger. Throughout this ordeal, themes of loyalty, duty, and sacrifice emerge, creating a compelling narrative about law enforcement's struggles and the high cost of justice on both personal and professional fronts.