Dr. Hess Green, an African-American anthropologist, becomes cursed with an insatiable thirst for blood after being stabbed by his deranged assistant, George Meda, with an ancient ceremonial dagger. This curse turns him into an immortal vampire. As Hess grapples with his newfound bloodlust, he continues his work and attempts to maintain a semblance of normal life. His struggle is intensified by the conflicting emotions wrought by his condition—he is simultaneously repulsed by and dependent upon his need for human blood. Hess's life takes another turn when George's estranged wife, Ganja, arrives searching for her missing husband.

Hess and Ganja develop an intense and complicated relationship as they merge their fates. Initially, Ganja remains unaware of Hess's vampiric nature but soon becomes entwined in his dark, supernatural world. The film explores themes of addiction, desire, and the clash between spirituality and physicality, weaving in elements of African-American culture and identity. The narrative delves deeply into their emotional turmoil, their shifting power dynamics, and their complex interplay of love and survival. Against a backdrop of haunting visuals and a moody soundtrack, the story evolves into a compelling study of transformation and the human condition.