Twenty-five years after a series of brutal murders shocked the quiet town of Woodsboro, a new killer dons the Ghostface mask and begins targeting a group of teenagers. This resurgence of violent killings forces the young residents to revisit the grim history of their home town. Amongst them is Samantha Carpenter, who harbors a personal connection to the original killings. As the body count rises and the familiar game of phone calls and threats unfolds, the new victims must unlock the motive behind the killer's actions and their possible target before they too are cut from the story – quite literally.

The return of Ghostface sends shockwaves through the community and draws the attention of the original survivors of the Woodsboro murders. Sidney Prescott, the resilient target of the initial killings, Gale Weathers, a journalist who made her career covering the series of murders, and Dewey Riley, the former sheriff who has been through this ordeal multiple times, find themselves pulled back into the nightmarish sequence of events. Their experiences and insights become crucial as they join forces with the new potential victims. Together, they must peel away the layers of mystery shrouding the current bloodshed, confront their own traumas, and attempt to stop the spree before they find themselves victims of the merciless killer known as Ghostface.