Dr. Misty Calhoun, a marine biologist specializing in shark conservation, is invited by pharmaceutical billionaire Carl Durant to consult on a top-secret project at his isolated aquatic facility. Upon arrival, she discovers that Durant has been experimenting on bull sharks, enhancing their cognitive abilities for the dual purposes of military use and advancing medical research. The team, including ex-Navy SEAL Trent Slater, scientist Mike Shutello, and tech specialist Daniel Kim, quickly realizes that the sharks are far more intelligent and dangerous than anticipated.

As tensions rise and mistakes are made, the facility suffers catastrophic damage leading to flooding. The genetically enhanced sharks seize this opportunity to escape their confinements, posing a deadly threat to the crew. Trapped in the rapidly deteriorating complex with limited resources, Misty and the team must navigate the treacherous environment, outsmart the super-intelligent predators, and find a way to stop them before they reach open waters and wreak havoc on the unsuspecting world. The battle for survival intensifies, with trust eroding and pressure mounting as the true extent of Durant's recklessness becomes apparent.