Having survived the latest round of killings in Woodsboro, the survivors attempt to leave the trauma behind and start anew. They relocate to New York City, hoping to find anonymity and safety amidst the bustling streets and towering skyscrapers. However, they soon realize that they cannot escape their past. A new Ghostface killer emerges and begins a terrifying game of cat and mouse. The survivors are forced to confront the reality that they might never be free from the shadow of Ghostface.

As the new killer strikes with calculated brutality, the group must rely on their wits and each other to stay alive. The crowded, urban landscape of New York presents a stark contrast to the quiet suburban life of Woodsboro, providing the killer with countless places to hide and a myriad of potential victims. Fear spreads as the body count rises, and the survivors must unravel the mystery before they too become statistics in the city that never sleeps.