In a post-apocalyptic desert wasteland where humanity is broken, and almost everyone is crazed fighting for the necessities of life, Max Rockatansky, a loner and former captive of the warlord Immortan Joe, finds himself caught up in a desperate escape attempt. Immortan Joe controls one of the last sources of clean water, enslaving many to enforce his will. When Imperator Furiosa, one of Joe's war captains, veers off-course during a routine fuel run, she signals a rebellion that could tilt the balance of power. Furiosa has taken something irreplaceable from Joe, and he will stop at nothing to reclaim it.

The chase begins as Furiosa speeds across the desert in her armored War Rig, seeking her birth land, which she believes will offer asylum and redemption. Max becomes an unwilling participant in the flight, initially self-interested, but increasingly influenced by Furiosa and her quest. They are joined by a group of Joe's former captives, yearning for freedom and a better life. Together, they must outwit and outfight Joe's relentless forces in high-speed battles across the harsh desert landscape, pushing their vehicles and themselves to the limit. With precious few resources and seemingly insurmountable odds, the band of escapees must forge alliances and fight fiercely if they are to survive the brutal fury of the road.