Two American brothers, Jan and Todd Wolfhouse, travel to Germany to spread their grandfather's ashes at Oktoberfest. During their visit, they stumble upon a secret, centuries-old competition described as a "Fight Club" with beer games. Intrigued and somewhat out of their league, they lose badly and are humiliated by the German team. Before leaving, the brothers are informed that the competition they participated in is called Beerfest, an underground beer games tournament. They vow to return to the United States, assemble a team of their old college friends, and train for the next year's Beerfest to redeem their national pride and win against the German team.

The team the brothers assemble consists of unique characters, each with a special skill that could contribute to their overall success in beer games: Phil, a scientist and an old friend with a knack for beer pong; Landfill, a man with a nearly insatiable appetite for beer; and Barry, a once great beer gamer who has since lost his confidence. Together, they undergo a rigorous and unconventional training regimen filled with a lot of beer, bonding, and breaking personal limits. As they prepare, the team also uncovers a family secret that adds a personal stake to the competition. The brothers' journey towards Beerfest becomes not just about winning the games, but also about settling old scores and rediscovering brotherhood.