In 19th century Europe, a feared and solitary monster hunter with a forgotten past, Gabriel Van Helsing, is dispatched by a secretive Vatican organization to Transylvania. His mission is to assist the last of a family line, Anna Valerious, in defeating Count Dracula, who has evaded the grasp of his ancestors for centuries. Dracula is attempting to bring to life his undead progeny, and his success would ensure eternal damnation for the Valerious family. Van Helsing, equipped with advanced weaponry and his iconic hat and coat, heads to the mountainous region fraught with supernatural threats.

Upon arrival, Van Helsing and Anna quickly encounter the Count's brides and various other creatures serving him, including the tragic figure of the Wolf Man and the misshapen Igor. As they delve deeper into the Count's dark plans, they discover his connection to an enigmatic experiment that could grant him unimaginable power and irreversible dominion over life and death itself. Van Helsing grapples with his obscured history while battling his own internal monsters, and as he forges a bond with Anna, they prepare to face Dracula and the terrifying forces at his command, setting the stage for a confrontation steeped in ancient curses and family legacies.