Six years after the events of the previous film, the mysterious Michael Myers is once again at large after a sinister cult helps him escape custody. Meanwhile, the only survivor of his last rampage, Jamie Lloyd, is pregnant and held captive by the cult members who worship Michael as a dark entity. On Halloween night, Jamie gives birth and manages to escape with her newborn, seeking to put an end to the cycle of terror. However, her freedom is short-lived as Michael relentlessly pursues her through the shadowy outskirts of Haddonfield, leaving a trail of horror in his wake.

In Haddonfield, Tommy Doyle, a survivor of Michael's Halloween carnage from years past, is now an adult obsessed with finding the truth behind Michael Myers' invincibility and motives. Teaming up with Dr. Loomis, Michael's former psychiatrist, and Kara Strode, who lives in the Myers house with her son and family unaware of the dark past, Tommy delves into the mystery that surrounds his childhood boogeyman. As the night unfolds, they all find themselves caught in the web of an ancient and malevolent curse that drives Michael and discover the chilling connection to the Strode family. Together, Tommy, Dr. Loomis, and Kara must confront the pure evil that is Michael Myers before it's too late, as the shapes of their own fears come to life.