Dr. Jack Hammond is a successful surgeon who has a strained relationship with his teenage son, Chris, largely due to the demands of his career and the distance it creates between them. While Jack is disciplined, responsible, and somewhat uptight, Chris is a carefree high school student prone to trouble. When Jack’s colleague, Dr. Amy Larkin, introduces him to a mysterious potion that allows minds to switch bodies, an accidental mishap occurs, causing Jack and Chris to swap places.

As they navigate their new circumstances, both father and son find themselves struggling to adapt to each other's lives. Jack experiences the chaotic world of high school, juggling classes and teenage social dynamics, while Chris must manage his father’s professional duties at the hospital, dealing with patients and emergency situations. Through these humorous and challenging experiences, they gain a deeper understanding of each other's pressures and perspectives, which changes their relationship profoundly.