In a modern-day Chicago, marked by rampant gang violence, the girlfriends of rival gang members, led by Lysistrata, are desperate for change after a child is killed in a drive-by shooting. Inspired by a classical Greek play, Lysistrata devises a bold strategy to abstain from sexual activity with their partners until the men agree to cease hostilities and seek peaceful resolutions. This decision fractures relationships, stirs community tensions, and garners significant public attention, including the involvement of political and religious leaders who weigh in on the escalating crisis.

As the women steadfastly hold to their plan amidst intense social and personal pressures, their movement gains traction and sparks widespread debate. Their actions challenge deeply ingrained behaviors and highlight the impacts of violence on their communities. The narrative intricately weaves through the lives affected by the initiative, portraying both the resolve of the women and the turmoil faced by their partners and adversaries. Amidst mounting pressure, hope and skepticism coexist as the unfolding events test the limits of commitment, solidarity, and the yearning for peace in a city marred by conflict.