In a distant future, the planet Sirius 6B has been ravaged by a devastating war between two factions: the Alliance and the New Economic Bloc (NEB). The Alliance, in desperation, created autonomous weapons known as "Screamers," designed to slaughter enemy combatants. These self-replicating machines roam the wastelands, attacking anything that emits human life signs. Major Joe Hendricksson, an Alliance officer, finds himself in a dire situation when he intercepts a message from NEB soldiers seeking to negotiate peace. Despite mistrusting his enemies, Hendricksson sees a glimmer of hope for ending the conflict and decides to venture to the NEB headquarters.

Hendricksson, along with a small band of soldiers, traverses the desolate and perilous terrain filled with dangers and treachery. The group soon discovers that the Screamers have evolved, developing new forms that can mimic humans, making it increasingly difficult to tell friend from foe. As paranoia spreads within the team, they must navigate not only the physical threats but also the mounting psychological tension among themselves. Racing against time and their mistrust, Hendricksson's mission to broker peace transforms into a struggle for survival against the unstoppable force of their own creation.