After Charlie Sheen and Lindsay Lohan have a bizarre encounter, Sheen meets an untimely and comical demise, setting the stage for a sequence of absurd and frightening events. Sheen's three children are discovered alone in a cabin in the wilderness, and are later retrieved and adopted by Sheen's brother, Dan, and his wife, Jody. The couple has been eagerly trying to have a child and sees the adoption as a blessing. However, the children display strange behavior, indicative of their time in isolation. Unsettling occurrences unfold in their home, leaving Dan and Jody perplexed about their new family dynamics.

The peculiar happenings intensify, prompting Jody to investigate further. Her search for answers leads her to an encounter with a mysterious psychic who warns her of the supernatural forces at play. Meanwhile, Dan is drawn into a bizarre set of his own challenges, including everything from his performances in a primate-research facility to inexplicable experiences at home. The couple's exploration into the source of the chaos around them exposes them to a range of parodies of famous pop culture and cinematic moments, revealing that their situation may be part of a much more extensive and surprising phenomenon. As they struggle to restore normalcy to their lives, they find themselves dodging one unexpected turn after another.