Ivan Locke, a construction manager, leaves his job site and begins a solo drive from Birmingham to London. He abandons one of the biggest concrete pours in European history and the responsibilities at home, which include his wife and two sons. The entire film takes place within the confines of his car as he makes a series of phone calls to both handle the work crisis and address personal issues arising from a one-night stand many months ago that now requires immediate attention.

Throughout the drive, Locke's professional reputation and personal relationships begin to unravel. He attempts to guide his colleagues through the complex construction project while also managing the emotional fallout with his family. As he juggles multiple conversations and crises from behind the wheel, Locke's composed façade cracks, revealing a man grappling with the consequences of his past actions. The narrative focuses on his struggle to maintain control amidst the escalating chaos.