The narrative unfolds across several decades, tracing the epic saga of the Prescott family as they navigate the perils and opportunities of the ever-expanding American frontier. Initially, Zebulon Prescott sets out with his family on the treacherous journey westward, driven by the promise of a new life and fertile land beyond the Mississippi River. Their story encapsulates the pioneering spirit of the era, marked by encounters with rivers, plains, and the native tribes of the American West. As the Prescotts settle, their saga intertwines with the broader tapestry of American expansion, showcasing the push for gold, the building of the railways, and the lawless expanse of the frontier towns.

As the Prescott lineage progresses, the second generation continues to confront the challenges and changes on the western frontier. The stories of their lives capture the essence of the American dream, with each character symbolizing the varied paths of pioneers and settlers of the era. Through their eyes, viewers are presented with a panoramic view of American history, including the advent of the Civil War, the Gold Rush, and the creation of the transcontinental railroad. Their personal journeys reflect the changing landscape of America, embodying the hardships, conflicts, and triumphs that shaped the nation during its formative years.