While on a sniper mission, elite mercenary Quinn McKenna encounters an alien spaceship crash site and confronts the occupant: a Predator, which he narrowly manages to overpower. Before being captured by government agent Will Traeger, McKenna mails the alien technology he has retrieved to his home for safekeeping. Traeger aims to cover up the incident while harvesting the Predator's technology. Meanwhile, Quinn's autistic son Rory, considered a prodigy, receives the mailed alien tech and inadvertently triggers a homing beacon that alerts other Predators to Earth's location.

A group of former military prisoners, whose paths cross with McKenna's, become his unlikely allies. With Quinn's inside knowledge of the creature and the group's individual skills, they unite to protect Rory, who has been targeted due to his unique ability to understand the Predator's technology. Their mission becomes a two-fold fight for survival: to stop the Predators and evade the government forces led by Traeger, who have their own agenda and will stop at nothing to obtain alien technology. The group must navigate a deadly game of cat-and-mouse, facing off against an enemy far more technologically advanced and seemingly unbeatable.