Toula Portokalos, now in her fifties, learns that her late father's last wish was for the family to reunite with his childhood friends and extended relatives in Greece. To honor his memory, Toula and her husband, Ian, decide to embark on a trip to the small Greek village where her father grew up. The extended Portokalos family, known for their larger-than-life personalities and hilarious antics, enthusiastically joins the journey. Though initially intended as a simple family reunion, the trip becomes an adventure filled with unexpected twists, cultural clashes, and the comedic challenges of navigating a sprawling Greek family dynamic.

Upon arriving in the picturesque village, the Portokalos clan faces the daunting task of connecting with distant relatives who have their own intriguing stories and eccentricities. As the family embraces their Greek roots, they encounter heartwarming reunions and quirky quests to uncover long-lost traditions. Toula finds herself reflecting on life’s transitions, her identity, and the importance of familial love and history. As new bonds form and old ones are re-affirmed, the trip sets the stage for heartfelt discoveries and joyous celebrations. Throughout their journey, Toula is reminded about the significance of cherishing family ties and remaining open to new possibilities, leaving behind a legacy of unity and love.