Seven years after the tragic events of his fifth birthday, the young and seemingly innocent Damien Thorn lives with his uncle Richard Thorn, the wealthy industrialist, and his family. Unaware of his true nature, Damien has grown into a thoughtful adolescent, surrounded by the luxury his uncle's success affords. As Damien begins to attend military academy, Richard takes him under his wing, seeing great potential in his nephew. Despite the comforts of his new life, there is an unsettling undercurrent for Damien, as strange accidents and mysterious deaths start to surround him, hinting at the darker truth of his destiny.

Meanwhile, anyone who suspects the ominous origins of Damien's birth meets a horrific and untimely demise. As the death count rises, a journalist begins to unravel the terrifying prophecy linked to Damien's birth. Throughout this time, Damien experiences conflicting feelings and confusions about his identity as he learns about the malevolent prophecy, pitting him against his own instinct for self-preservation and the increasingly alarming facts that come to light. The tension builds as key characters inch closer to the realization of Damien's true identity, and the struggle between forces seen and unseen takes shape, setting the stage for a chilling confrontation between good and evil.