In Southern California, Robert Wakefield, a conservative judge, is appointed by the President as the new drug czar, tasked with leading the nation's drug policy and combating an escalating war on drugs. Unbeknownst to him, his own teenage daughter, Caroline, has become ensnared in the drug world, struggling with addiction to crack cocaine and rapidly descending into the hands of dealers and criminals. As Wakefield grapples with drug issues on a national scale, his personal life becomes increasingly compromised, highlighting the struggle many families face in a society where drug abuse pervades.

Meanwhile, in Mexico, a state police officer named Javier Rodriguez finds himself and his partner, Manolo Sanchez, in the throes of local drug cartels' corruption. After a significant drug bust, Javier navigates the treacherous politics and power plays between the police force and the drug lords. Simultaneously, on the other side of the border, the pregnant wife of a wealthy drug baron, Helena Ayala, is thrown into chaos when her world is turned upside down by her husband's arrest. Plunged into the criminal underworld, she must take dramatic steps to secure her family's future, revealing the international implications and personal costs of the drug trade. The intertwining stories shed light on the complex and brutal realities of the global narcotics industry and its far-reaching effects.