The film begins by chronicling the early life of a young Mexican artist who suffers a catastrophic trolley accident, leaving her with lifelong medical problems and chronic pain. During her difficult recovery, she discovers her passion for painting, using it as a means of expressing her physical and emotional suffering. Her unique style and compelling self-portraits quickly draw attention, and she immerses herself in the vibrant and politically charged art scene of Mexico. It is within this circle that she meets and falls in love with a charismatic but controversial artist, who becomes both her mentor and husband.

Their passionate relationship is marked by mutual admiration, tempestuous arguments, and infidelities. As her career grows, she grapples with personal hardships and complex relationships, while gaining international acclaim for her deeply personal and evocative works. Throughout her journey, she forms relationships with a range of prominent figures, including a Russian revolutionary and sculptor, which further challenge and shape her worldview. The narrative explores her resilience and unyielding spirit, portraying her as an indomitable figure who confronts life's adversities with artistic brilliance and a defiant attitude. As the plot progresses, her legacy as an artist and cultural icon begins to solidify, leaving a lasting impact on the world.