Since his triumph over the tyrant Memnon, Mathayus’s kingdom has fallen and he's lost his queen to plague. Now, the once-great Scorpion King has become a mercenary for hire, selling his fighting skills to the highest bidder and seeking to reclaim his lost glory. When Horus, the powerful king of Egypt, is threatened by a formidable adversary, Talus, he recruits Mathayus to aid in the conflict. Talus, the ruthless younger brother of Horus, seeks to usurp his brother's throne by obtaining a fabled ancient treasure, which is key to solidifying his power and dominance over the kingdom.

Tasked with thwarting Talus's plans, Mathayus embarks on a journey filled with harrowing obstacles and unlikely allies. Among those who join him are a cunning and exotic ninja, a silent warrior with a reputation to match Mathayus’s own legend, and an eccentric inventor with his unique contraptions and strategies. The group traverses ominous terrains and battles a series of brutal competitors, including formidable warriors and inhuman assailants. Amidst the backdrop of political intrigue and ancient sorcery, the Scorpion King’s grit, skill, and courage are put to the ultimate test as he confronts not only his enemies but also the consequences of his own dwindling legacy.