The President of the United States travels on the presidential aircraft, known as Air Force One, after making a public stance in Moscow against international terrorism. During the flight back to the U.S., a group of terrorists, disguised as a Russian news crew, hijack the plane. Their leader, a radical political zealot, demands the release of a rogue general imprisoned in his homeland. The terrorists take hostages, including the President’s family and staff, and threaten to execute them if their demands are not met.

Undetected by the hijackers, the President, a veteran with combat experience, remains on board instead of escaping in a rescue pod. He becomes the last line of hope for his fellow passengers and the nation. Covertly communicating with the Vice President and the National Security team from the besieged aircraft, the President makes a desperate attempt to negotiate, strategize, and regain control of the plane while maintaining the façade of a compliant hostage to keep everyone on board safe. With every minute that passes, the stakes are raised as the world watches a volatile situation unfold at 25,000 feet.