Sherlock Holmes and his steadfast partner Dr. John Watson join forces once again when Europe is threatened by a series of anarchist attacks. As they unravel a trail of chaos, it becomes apparent that the shadowy criminal mastermind Professor James Moriarty is orchestrating the events. The duo's investigation reveals Moriarty's broader scheme to instigate a global conflict, which would enrich him through his investments in war-related industries. Recognizing the gravity of the threat, Holmes and Watson must act swiftly to prevent the impending disaster. In the process, the detective’s peculiar intellect and unorthodox methods clash with Moriarty’s cunning and ruthlessness.

Their pursuit leads them across the continent, from England to France, Germany, and finally Switzerland, engaging in both mental and physical battles with Moriarty’s web of agents. Along the way, they are aided by a gypsy fortune-teller named Simza, who is searching for her missing brother caught up in the anarchist movement. With her help, they decipher the volatile political climate, and Holmes applies his signature disguise and deduction techniques to stay one step ahead of Moriarty. As Holmes and Watson navigate through perilous territory, their friendship, wit, and valor are put to the ultimate test against an adversary who has no moral boundaries.