Two years after the events of the first film, the bodyguard Michael Bryce continues his friendship with hitman Darius Kincaid as they embark on a new adventure. Bryce, stripped of his bodyguard license, is on a company-mandated sabbatical when he’s suddenly pulled back into action by Darius's even more volatile wife, Sonia. Her demand for his assistance in rescuing Darius from the Mafia propels Bryce into a chaotic struggle, for which he's woefully unprepared, as he's promised his therapist to avoid any firearms or violence.

The trio's mission rapidly intertwines with a global plot when they come across Interpol agent Bobby O'Neill. O'Neill recruits them to prevent a catastrophic attack in Europe orchestrated by a vengeful and powerful madman. Their journey is fraught with deadly cadres of mercenaries and international intrigue. Amidst shooting, chasing, and escaping from a multitude of threats, Bryce grapples with his own issues, namely his rocky relationship with Darius and the larger-than-life presence of Sonia, who both constantly berate and belittle him, while also showing glimpses of camaraderie. The dynamics between the dysfunctional trio turn into a source of humor and reluctant teamwork as they attempt to put aside their differences to prevent widespread chaos.